Ethanol → 1,2-Benzisothiazol-4-ol, 7-amino-

HRID 1449115Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1449115
CO.C(O)C.C(OC(=O)C)(=O)C.[NH:13]([C:17]1[C:25]2[S:24][N:23]=[CH:22][C:21]=2[C:20]([O:26]C(=O)C)=[CH:19][CH:18]=1)C(C)=O>C(O)(=O)C.C(O)CC>[NH2:13][C:17]1[C:25]2[S:24][N:23]=[CH:22][C:21]=2[C:20]([OH:26])=[CH:19][CH:18]=1

Komponenten

7

Edukt 4

HCID 702EthanolHCID 887MethanolHCID 7918Acetic AnhydrideHCID 203499417-Acetamino-4-acetoxy-1,2-benzisothiazole2×

Produkt 1

HCID 1356171871,2-Benzisothiazol-4-ol, 7-amino-

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittel2×HCID 10311-PropanolLösungsmittel

Versuchsvorschrift

This reduction is as a rule carried out under atmospheric pressure or in a closed vessel under superatmospheric pressure, with or without simultaneous heating. The reaction may be carried out in the presence of a diluent or solvent, for example, a lower alcohol, e.g. methanol, ethanol or preferably propanol, or in the acid required for the reduction, preferably in acetic acid, or in the acylating reaction medium of acetic acid and acetic anhydride, described above, in which 7-acetamino-4-acetoxy-1,2-benzisothiazole is obtained. 7-Acetamino-4-acetoxy-1,2-benzisothiazole can subsequently be deacylated in the above manner to give 7-amino-4-hydroxy-1,2-benzisothiazole.

Aufarbeitung

  1. customcarried out under atmospheric pressure or in a closed vessel under superatmospheric pressure
  2. customThe reaction
  3. customis obtained

Quellen und Nachweise

ORD-Eintrag
ord-38f6917caac942a9a95e10acc735d2e3
Quelldatensatz
uspto-grants-1980_02
Patentnummer
US04189433

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