Acetic Acid → HCID 72819808, Verbindung

Reaktionsgleichung

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[N:17]([O-])=[O:18].[Na+].C(O)(=[O:23])C>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:17][OH:18])[C:9]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[O:23])=[CH:4][CH:3]=1

Komponenten

Versuchsvorschrift

A solution of 1-(4-fluoro-phenyl)-2-pyridin-4-yl-ethanone (6.45 g, prepared according to the method described for Reference Example 11 in the specification of International Patent Application No. WO98/56788) in acetic acid (50 ml) was treated with a solution of sodium nitrite (4.14 g) in water (30 ml) at 10° C. The reaction mixture was stirred at room temperature for 16 hours then treated with water (150 ml) and then filtered to give the title compound as a white solid.