Ammonium Hydroxide → 2-amino-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one

HRID 1454971Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1454971
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][C:10](=[O:20])[C:11]=2[C:12]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=2[F:19])[N:7]=1.[NH4+:21].[Cl-].[NH4+].[OH-]>O>[NH2:21][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][C:10](=[O:20])[C:11]=2[C:12]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=2[F:19])[N:7]=1

Komponenten

5

Edukt 3

HCID 14923Ammonium HydroxideHCID 25517Ammonium ChlorideHCID 575312262-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one

Produkt 1

HCID 575312362-amino-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To 2-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one (1.1 g, 3.77 mmol) was added NH4Cl (100 mL) and NH4OH (100 mL). The resulting solution was heated to 90° C. and stirred for 16 hrs until complete. The reaction was cooled to ambient temperature and diluted with H2O (500 mL) until a precipitate formed. The solid precipitate was collected and dried to yield the title compound.

Aufarbeitung

  1. temperatureThe reaction was cooled to ambient temperature
  2. customformed
  3. customThe solid precipitate was collected
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-08ee52dc7da84685874ac0be4d7a3057
Quelldatensatz
uspto-grants-2009_01
Patentnummer
US07482345B2

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