Pyridine → HCID 15019923, Verbindung

HRID 1460416Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1460416
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.N1C=CC=CC=1.[N+](C1C=CC=CC=1)([O-])=O.[C:33](Cl)(=[O:36])[CH:34]=[CH2:35]>O.O1CCCC1>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]2[CH:17]=[CH:16][C:14]([NH:15][C:33](=[O:36])[CH:34]=[CH2:35])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:6][CH:7]=1

Komponenten

7

Edukt 4

HCID 1049PyridineHCID 7416NitrobenzeneHCID 13140Acryloyl chlorideHCID 1176864-((4-Aminophenyl)sulfonyl)phenol

Produkt 1

HCID 15019923HCID 15019923, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 4-(4'-hydroxyphenylsulfonyl)aniline (23.3 g), pyridine (9.4 g) and nitrobenzene (1 ml) is added to 400 ml of tetrahydrofuran. To the ice-cooled solution, 9.0 g of acrylic acid chloride is added dropwise and stirred for 30 min. The stirred mixture is added to 2,000 ml of water and the precipitating crystal is separated by filtration. The resulting crystal is recrystallized with ethanol to obtain the end compound in an amount of 28.5 g. The structure of this compound is verified by IR, NMR and mass spectra.

Aufarbeitung

  1. additionis added dropwise
  2. customthe precipitating crystal is separated by filtration
  3. customThe resulting crystal is recrystallized with ethanol
  4. customto obtain the end compound in an amount of 28.5 g

Quellen und Nachweise

ORD-Eintrag
ord-342b39efb741490ab8fb551f708e8e4e
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05071738

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