Water → HCID 19982193, Verbindung

HRID 1460550Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1460550
BrC1C=CC=C[C:3]=1[C:8]1([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])[O:12][CH:11]([CH3:13])[CH2:10][O:9]1.[OH:22][C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C(=O)C>[Cl:21][C:15]1[CH:16]=[C:17]([Cl:20])[CH:18]=[CH:19][C:14]=1[C:8]1([CH2:3][O:22][C:23]2[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=2)[O:12][CH:11]([CH3:13])[CH2:10][O:9]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 79713-HydroxypyridineHCID 11430Potassium CarbonateHCID 19982196HCID 19982196, Verbindung

Produkt 1

HCID 19982193HCID 19982193, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

A mixture of 2-(bromophenyl)-2-(2,4-dichlorophenyl)-4-methyl-1,3-dioxolane (10 g.), 3-hydroxypyridine (3.8 g.) and potassium carbonate (5.5 g.) in N,N-dimethylacetamide (90 ml.) was refluxed with stirring for 18 hours. After the mixture was allowed to cool, it was poured into water and extracted with toluene. The toluene fraction, thereby obtained, was washed with 5% aqueous sodium hydroxide and evaporated to yield 3-[[2-(2,4-dichlorophenyl)-4-methyl-1,3-dioxolan-2-yl]methoxy]pyridine as an oil.

Aufarbeitung

  1. temperaturewas refluxed
  2. temperatureto cool
  3. extractionextracted with toluene
  4. customThe toluene fraction, thereby obtained
  5. washwas washed with 5% aqueous sodium hydroxide
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-29004a64b67e4c0bb0bb0f60e67f2084
Quelldatensatz
uspto-grants-1991_12
Patentnummer
US05071862

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