6-[1-Oxo-4-(4-phenylpiperazinyl)-butyl]-3,4-dihydrocarbostyril → 6-[1-Hydroxy-4-(4-phenyl-1-piperazinyl)butyl]-3,4-dihydrocarbostyril

HRID 1462537Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1462537
[O:1]=[C:2]([C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[CH2:22][CH2:21]2)[CH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1.[H][H]>O.[Pd]>[OH:1][CH:2]([C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[CH2:22][CH2:21]2)[CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:10][CH2:11]1

Komponenten

5

Edukt 2

HCID 30670756-[1-Oxo-4-(4-phenylpiperazinyl)-butyl]-3,4-dihydrocarbostyrilHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 128335176-[1-Hydroxy-4-(4-phenyl-1-piperazinyl)butyl]-3,4-dihydrocarbostyril

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

2.0 Grams of 6-[1-oxo-4-(4-phenylpiperazinyl)-butyl]-3,4-dihydrocarbostyril and 0.5 g of palladium black were dispersed in 80 ml of water and stirred at a room temperature under 2 atmospheric pressure of hydrogen gas for 5 hours. The reaction mixture was filtered for removing the palladium black and the mother liquor was concentrated under a reduced pressure and the residue thus obtained was crystallized from acetone and a small amount of ethanol. The crude crystals thus obtained were collected by filtration and recrystallized from isopropanol to obtained 1.5 g of 6-[1-hydroxy-4-(4-phenyl-1-piperazinyl)butyl]-3,4-dihydrocarbostyril in colorless needle like crystals.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customfor removing the palladium black
  3. concentrationthe mother liquor was concentrated under a reduced pressure
  4. customthe residue thus obtained
  5. customwas crystallized from acetone
  6. customThe crude crystals thus obtained
  7. filtrationwere collected by filtration
  8. customrecrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-3c865c4935334f499a844acdb97058b3
Quelldatensatz
uspto-grants-1984_07
Patentnummer
US04460593

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