Hydrogen Bromide → hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one

HRID 1463113Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1463113
Cl[C:2]1[C:7](=[O:8])[CH2:6][CH2:5][CH2:4][C:3]=1[CH:9]1[CH2:15][CH2:14][CH2:13][CH2:12][N:11]([CH3:16])[C:10]1=[O:17].Br.O>C(O)(=O)C>[OH:8][C:7]1[CH:2]=[C:3]([CH:9]2[CH2:15][CH2:14][CH2:13][CH2:12][N:11]([CH3:16])[C:10]2=[O:17])[CH:4]=[CH:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 260Hydrogen BromideHCID 962WaterHCID 28175763-(2-Chloro-3-oxocyclohex-1-enyl)-hexahydro-1-methylazepin-2-one

Produkt 1

HCID 11746121hexahydro-3-(3-hydroxyphenyl)-1-methyl-2H-azepin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel3×

Versuchsvorschrift

Using acetic acid as solvent. A solution of 3-(2-chloro-3-oxocyclohex-1-enyl)-hexahydro-1-methylazepin-2-one (5.12 g) in glacial acetic acid (50 ml) was treated with 48% HBr in acetic acid (2 ml). After 12 hours the reaction mixture was poured on to water and the resulting precipitate removed by filtration to yield the title compound m.p. 192°-3° C. (EtOAc).

Aufarbeitung

  1. customthe resulting precipitate removed by filtration

Quellen und Nachweise

ORD-Eintrag
ord-4a5f25e5f58f4655ad01fc46ba1b8ba9
Quelldatensatz
uspto-grants-1984_07
Patentnummer
US04463177

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