Bromine → HCID 86657727, Verbindung

HRID 1465598Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1465598
[CH3:1][C:2]1[C:7]([C:8](=[O:10])[CH3:9])=[C:6]([CH3:11])[CH:5]=[C:4]([CH3:12])[N:3]=1.[Br:13]Br>Br.C(O)(=O)C>[BrH:13].[Br:13][CH2:9][C:8]([C:7]1[C:2]([CH3:1])=[N:3][C:4]([CH3:12])=[CH:5][C:6]=1[CH3:11])=[O:10]

Komponenten

5

Edukt 2

HCID 24408BromineHCID 2681241-(2,4,6-Trimethylpyridin-3-yl)ethan-1-one

Produkt 1

HCID 86657727HCID 86657727, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittel2×HCID 260Hydrogen BromideLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of 1-(2,4,6-trimethylpyridin-3-yl)ethanone (5.0 g, 30.6 mmol) in 33% HBr in acetic acid solution (10.2 mL) was added bromine (1.57 ml, 30.6 mmol) in acetic acid (10.2 mL) dropwisely. The reaction was stirred at 70° C. for 2.0 h. The solution was cooled to room temperature and washed with ether. The residue was dried under reduced pressure to give 2-bromo-1-(2,4,6-trimethylpyridin-3-yl)ethanone hydrobromide, which was used directly for the next step without further purification.

Aufarbeitung

  1. temperatureThe solution was cooled to room temperature
  2. washwashed with ether
  3. customThe residue was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-9d6118915bef4fbf99a9b421e3fa4b44
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US08999983B2

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