1,2-Dichloroethane → Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

HRID 1465990

Reaktionsgleichung

Reaktionsgleichung von HRID 1465990
[F:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[C:5]([F:10])=[C:4]([F:11])[C:3]=1[F:12].C(Cl)C[Cl:15].Cl.[N:18]12[CH2:25][CH2:24][CH:21]([CH2:22][CH2:23]1)[CH:20]([CH2:26][C:27](O)=[O:28])[CH2:19]2>C(N(CC)C(C)C)(C)C.ClCCl>[ClH:15].[N:18]12[CH2:23][CH2:22][CH:21]([CH2:24][CH2:25]1)[CH:20]([CH2:26][C:27]([O:8][C:7]1[C:2]([F:1])=[C:3]([F:12])[C:4]([F:11])=[C:5]([F:10])[C:6]=1[F:9])=[O:28])[CH2:19]2

Komponenten

6

Edukt 3

HCID 111,2-DichloroethaneHCID 13041PentafluorophenolHCID 230241472-(Quinuclidin-3-yl)acetic acid hydrochloride

Produkt 1

HCID 86610796Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 81531DiisopropylethylamineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

358 mg (1.94 mmol) of pentafluorophenol, 120.5 mg (0.63 mmol) of EDC and 1 drop of N,N-diisopropylethylamine are added to a solution of 100 mg (0.49 mmol) of 1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride in 4 ml of dichloromethane at 0° C. The mixture is stirred at room temperature for 18 h. The contents of the flask are concentrated in vacuo and dried under high vacuum. The resulting crude product is employed without further purification in the following stages.

Aufarbeitung

  1. concentrationThe contents of the flask are concentrated in vacuo
  2. customdried under high vacuum
  3. customThe resulting crude product is employed without further purification in the following stages

Quellen und Nachweise

ORD-Eintrag
ord-cd0ce5370a1e4438a73660e56efb6577
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09000008B2

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