[CH3:1][N+:2]1([CH3:26])[C@@H:7]2[C@@H:8]3[O:10][C@@H:9]3[C@H:3]1[CH2:4][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)[C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)=[O:13])[CH2:6]2.O.[Br-:28].[CH2:29]([OH:51])[C@H:30]1[O:35][C@H:34]([O:36][C@H:37]2[O:42][C@H:41]([CH2:43][OH:44])[C@@H:40]([OH:45])[C@H:39]([OH:46])[C@H:38]2[OH:47])[C@H:33]([OH:48])[C@@H:32]([OH:49])[C@@H:31]1[OH:50].[NH2:52][C@H:53]([C:58]([OH:60])=[O:59])[CH2:54][CH:55]([CH3:57])[CH3:56].CO>O>[CH3:1][N+:2]1([CH3:26])[C@@H:3]2[C@@H:9]3[O:10][C@@H:8]3[C@H:7]1[CH2:6][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)[C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)=[O:13])[CH2:4]2.[OH2:35].[Br-:28].[CH2:43]([OH:44])[C@H:41]1[O:42][C@H:37]([O:36][C@H:34]2[O:35][C@H:30]([CH2:29][OH:51])[C@@H:31]([OH:50])[C@H:32]([OH:49])[C@H:33]2[OH:48])[C@H:38]([OH:47])[C@@H:39]([OH:46])[C@@H:40]1[OH:45].[NH2:52][C@H:53]([C:58]([OH:60])=[O:59])[CH2:54][CH:55]([CH3:57])[CH3:56]Tiotropium bromide (1.2 g), trehalose dehydrate (0.6 g), and L-leucine (0.6 g) were dissolved into methanol (60 ml). The solutions were combined by shaking. Water (60 ml) was added and shaken until dissolution occurred. The resultant solution was spray dried according to the parameters outlined above.
Wird geladen…