5-Amino-2-methylphenol → (3-Hydroxy-p-tolyl)urea

HRID 1474007

Reaktionsgleichung

Reaktionsgleichung von HRID 1474007
[NH2:1][C:2]1[CH:7]=[C:6]([OH:8])[C:5]([CH3:9])=[CH:4][CH:3]=1.[O-:10][C:11]#[N:12].[K+]>C(O)(=O)C.O>[OH:8][C:6]1[CH:7]=[C:2]([NH:1][C:11]([NH2:12])=[O:10])[CH:3]=[CH:4][C:5]=1[CH3:9]

Komponenten

5

Edukt 2

HCID 178185-Amino-2-methylphenolHCID 11378442Potassium cyanate

Produkt 1

HCID 85554(3-Hydroxy-p-tolyl)ureaAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

5-Amino-o-cresol (1 g, 8.12 mmol) was dissolved in glacial acetic acid (4.1 mL) and H2O (8.41E) ata 35° C. The potassium cyanate solution was added slowly with stirring until a with precipitate of the product appears. The rest is added quickly with vigorous agitation. After 24 h, the reaction mixture was diluted with H2O, cooled to 0° C. and filtered with suction, washed with H2O and dried under high vacuum to afford the product (1.3 g, 99% yield).

Aufarbeitung

  1. customata 35° C
  2. additionThe rest is added quickly with vigorous agitation
  3. filtrationfiltered with suction
  4. washwashed with H2O
  5. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-21b3510a094b40bbbbd088e7fbee27ad
Quelldatensatz
uspto-grants-2015_04
Patentnummer
US09018209B2

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