Bromine → HCID 86657727, Verbindung

HRID 1480656Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1480656
[CH3:1][C:2]1[C:7]([C:8](=[O:10])[CH3:9])=[C:6]([CH3:11])[CH:5]=[C:4]([CH3:12])[N:3]=1.[Br:13]Br>Br.C(O)(=O)C>[BrH:13].[Br:13][CH2:9][C:8]([C:7]1[C:2]([CH3:1])=[N:3][C:4]([CH3:12])=[CH:5][C:6]=1[CH3:11])=[O:10]

Komponenten

5

Edukt 2

HCID 24408BromineHCID 2681241-(2,4,6-Trimethylpyridin-3-yl)ethan-1-one

Produkt 1

HCID 86657727HCID 86657727, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittel2×HCID 260Hydrogen BromideLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of 1-(2,4,6-trimethylpyridin-3-yl)ethanone (5.0 g, 30.6 mmol) in 33% HBr in acetic acid solution (10.2 mL) was added bromine (1.57 ml, 30.6 mmol) in acetic acid (10.2 mL) dropwisely. The reaction was stirred at 70° C. for 2.0 h. The solution was cooled to room temperature and washed with ether. The residue was dried under reduced pressure to give 2-bromo-1-(2,4,6-trimethylpyridin-3-yl)ethanone hydrobromide, which was used directly for the next step without further purification.

Aufarbeitung

  1. temperatureThe solution was cooled to room temperature
  2. washwashed with ether
  3. customThe residue was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-eeaecffb40204d3a967c950611a05af3
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409902B2

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