Hydroxylamine → 5-Bromosalicylhydroxamic acid

HRID 1482862Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1482862
[Br:1][C:2]1[CH:11]=[C:6]([C:7](OC)=[O:8])[C:5]([OH:12])=[CH:4][CH:3]=1.[NH2:13][OH:14]>O1CCOCC1.O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:12])=[C:6]([CH:11]=1)[C:7]([NH:13][OH:14])=[O:8]

Komponenten

5

Edukt 2

HCID 787HydroxylamineHCID 77683Methyl 5-bromosalicylate

Produkt 1

HCID 220465-Bromosalicylhydroxamic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Methyl 5-bromosalicylate (5 g, 21.6 mmol) was dissolved in 90 mL 1,4-dioxane and 10 mL water. 10 mL 50% aqueous hydroxylamine solution was added and the mixture was stirred at ambient temperature for 24 hours. After concentrating the mixture under vacuum, water was added. The formed precipitate was filtered, washed with water and dried yielding 5-bromo-N,2-dihydroxybenzamide (4.12 g, 17.76 mmol) as off-white solid.

Aufarbeitung

  1. concentrationAfter concentrating the mixture under vacuum, water
  2. additionwas added
  3. filtrationThe formed precipitate was filtered
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b8376e5484c44bdcb4cda9ecc9ea4db0
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09416115B2

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