Water → HCID 84016145, Verbindung

HRID 1485028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1485028
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH3:18])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5])C.[Li+].[OH-].O>C1COCC1.CO>[CH3:18][N:9]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=[N:8]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 867185501-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester

Produkt 1

HCID 84016145HCID 84016145, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

1-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester (22.55 g; 91.37 mmol) was dissolved in THF/MeOH (1/1) and LiOH in water (7.67 g; 182.73 mmol) was added. After 16 hours at ambient temperature the reaction mixture was washed with EtOAc. The aqueous layer was acidified with 1 N HCl and extracted with EtOAc which was dried and evaporated afterwards.

Aufarbeitung

  1. washAfter 16 hours at ambient temperature the reaction mixture was washed with EtOAc
  2. extractionextracted with EtOAc which
  3. customwas dried
  4. customevaporated afterwards

Quellen und Nachweise

ORD-Eintrag
ord-3d7606fdbb88412eade1017ed4fd0554
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09422290B2

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