Diisopropylethylamine → 2-Phenyl-5,6-dihydro-1,2,4-triazolo[4,3-c]quinazolin-3-one

HRID 1489031Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1489031
Cl[C:2]1[N:11]2[C:12](=[O:21])[N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.C(N(CC)C(C)C)(C)C>C(O)C.C(Cl)(Cl)Cl.[Pd]>[C:15]1([N:13]2[C:12](=[O:21])[N:11]3[CH2:2][NH:3][C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=4[C:10]3=[N:14]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Komponenten

6

Edukt 2

HCID 81531DiisopropylethylamineHCID 15428837HCID 15428837, Verbindung

Produkt 1

HCID 1354844832-Phenyl-5,6-dihydro-1,2,4-triazolo[4,3-c]quinazolin-3-one

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A mixture of 5-chloro-2-phenyl-1,2,4-triazolo[4,3-c]-quinazolin-3-one (1 g, 3.4 mmol), N,N-diisopropylethylamine (1 ml, 6.7 mmol) and 10% Pd-C (200 mg) in ethanol was shaken under hydrogen at 50 psi overnight. The reaction was diluted with CHCl3 and filtered through Celite. The filtrate was evaporated under reduced pressure and the residue dissolved in dichloromethane. The solution was washed with water, dried over Na2 SO4 and evaporated under reduced pressure to yield 2-phenyl-5,6-dihydro-1,2,4-triazolo[4,3-c]quinazolin-3-one (Compound 2) as a white solid. m.p. 202°-204° C.

Aufarbeitung

  1. filtrationfiltered through Celite
  2. customThe filtrate was evaporated under reduced pressure
  3. dissolutionthe residue dissolved in dichloromethane
  4. washThe solution was washed with water
  5. customdried over Na2 SO4
  6. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-781b4b12552c485a9b2e55a82612fc99
Quelldatensatz
uspto-grants-1997_10
Patentnummer
US05677309

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