1,2-Dichloroethane → 4-chloro-N-phenethylbenzenesulfonamide

HRID 1490364Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1490364
C(Cl)CCl.[C:5]1([CH2:11][CH2:12][NH2:13])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[OH-].[Na+].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.O>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:13][CH2:12][CH2:11][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)(=[O:25])=[O:24])=[CH:19][CH:18]=1

Komponenten

7

Edukt 4

HCID 111,2-DichloroethaneHCID 1001PhenethylamineHCID 73984-Chlorobenzenesulfonyl chlorideHCID 14798Sodium Hydroxide

Produkt 1

HCID 7228614-chloro-N-phenethylbenzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 74236Tetrabutylammonium BromideKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

To a mixture of 150 ml of ethylene chloride and 150 ml of water are added 30.3 g of 2-phenylethylamine, 12 g of sodium hydroxide and 0.5 g of tetrabutylammonium bromide. 65.5 g of 4-chlorobenzenesulphonic acid chloride are added to the mixture in batches with stirring. After 30 minutes the organic phase is separated off, evaporated down and the residue is recrystallised from toluene.

Aufarbeitung

  1. customAfter 30 minutes the organic phase is separated off
  2. customevaporated down
  3. customthe residue is recrystallised from toluene

Quellen und Nachweise

ORD-Eintrag
ord-67782c2be1ce455088bebafa349fdd7c
Quelldatensatz
uspto-grants-1997_10
Patentnummer
US05681961

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