Tert-Butylamine → tert-Butyl-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-amine

HRID 14907

Reaktionsgleichung

Reaktionsgleichung von HRID 14907
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([NH:20][CH2:11][C:10]1[CH:13]=[CH:14][CH:15]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=2)[CH:9]=1)([CH3:19])([CH3:18])[CH3:17]

Komponenten

3

Edukt 2

HCID 6385Tert-ButylamineHCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehyde2×

Produkt 1

HCID 86603310tert-Butyl-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-amineAusbeute 97 %

Versuchsvorschrift

3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde (intermediate 1) and tert butylamine were coupled by procedure B. The yield was 97%. LC-MS showed the product had the expected M+H+ of 276. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 8.6 (d, 1H) 8.1 (s, 1H) 7.9 (d, 1H) 7.6 (d, 1H) 7.5 (m, 2H) 1.2 (s, 9H).

Quellen und Nachweise

ORD-Eintrag
ord-4b4178151fca419dac819ae8ff154559
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732444B2

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