Sulfuryl chloride → (2E)-2-[2-(4-chlorophenoxy)phenyl]-2-methoxyimino-N-methylacetamide

HRID 1491977

Reaktionsgleichung

Reaktionsgleichung von HRID 1491977
[CH3:1][NH:2][C:3](=[O:21])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:5]/[O:6][CH3:7].S(Cl)([Cl:25])(=O)=O>ClCCl.O>[CH3:1][NH:2][C:3](=[O:21])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:16]=[CH:17][C:18]([Cl:25])=[CH:19][CH:20]=1)=[N:5]/[O:6][CH3:7]

Komponenten

5

Edukt 2

HCID 24648Sulfuryl chlorideHCID 5483872(2E)-2-methoxyimino-N-methyl-2-(2-phenoxyphenyl)acetamide

Produkt 1

HCID 19429863(2E)-2-[2-(4-chlorophenoxy)phenyl]-2-methoxyimino-N-methylacetamideAusbeute 68,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of (E)-N-methyl-2-(2-phenoxyphenyl)-2-methoxyiminoacetamide (500 mg) in dichloromethane was cooled to 0° C., and sulfuryl chloride (285 mg) was dropwise added thereto. The resultant mixture was stirred at the same temperature for 2 hours, diluted with water and extracted with diethyl ether. The solvent was dried and removed, and the residue was subjected to HPLC with a mixture of hexane and ethyl acetate to give 382 mg of the objective compound.

Aufarbeitung

  1. extractionextracted with diethyl ether
  2. customThe solvent was dried
  3. customremoved
  4. additionthe residue was subjected to HPLC with a mixture of hexane and ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-e1b54a6892ab41e7b12785ca4b4efe79
Quelldatensatz
uspto-grants-1994_12
Patentnummer
US05371222

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