Water → N-(4-hydroxynaphthalen-1-yl)acetamide

HRID 1492127

Reaktionsgleichung

Reaktionsgleichung von HRID 1492127
O.[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([OH:13])=[CH:5][CH:4]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C(O)C>[OH:13][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([NH:2][C:14](=[O:16])[CH3:15])=[CH:4][CH:5]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 178151-Amino-4-naphthol

Produkt 1

HCID 235848N-(4-hydroxynaphthalen-1-yl)acetamideAusbeute 79,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Into a 500 ml round bottom flask (fitted with a magnetic stirrer), a 50:50 mixture of water:ethanol was combined with 4-amino1-naphthol (20 g, 125 mmole) until the solid was completely dissolved. The solution was warmed to boiling, and to it was added acetic anhydride (14 g) and the resulting solution was stirred for 1 hour. Upon cooling, crystals of N-(4-hydroxy-1-naphthyl)acetamide (20 g, 79% yield) formed.

Aufarbeitung

  1. customInto a 500 ml round bottom flask (fitted with a magnetic stirrer)
  2. dissolutionwas completely dissolved
  3. temperatureThe solution was warmed
  4. temperatureUpon cooling

Quellen und Nachweise

ORD-Eintrag
ord-9d36a4eb96e4449bbcd6f139e87e7d73
Quelldatensatz
uspto-grants-1994_12
Patentnummer
US05372931

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