Bromine → 6-Amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4h)-quinoxalinone hydrobromide

HRID 1492134Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1492134
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([CH3:13])([CH3:12])[C:6](=[O:14])[NH:5]2.[Br:15]Br>C(O)(=O)C>[BrH:15].[NH2:1][C:2]1[C:3]([Br:15])=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([CH3:12])([CH3:13])[C:6](=[O:14])[NH:5]2

Komponenten

4

Edukt 2

HCID 24408BromineHCID 152257137-Amino-3,3-dimethyl-3,4-dihydroquinoxalin-2(1H)-one

Produkt 1

HCID 199364056-Amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4h)-quinoxalinone hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

A solution of 6-amino-1,2-dihydro-2,2-dimethyl-3-(4H) -quinoxalinone (250 mg, 1.31 mmol ) in glacial acetic acid (4 ml ) is cooled using a water bath. Bromine (210 mg, 1.31 mmol) in acetic acid (0.25 ml) is added dropwise over a 5 minute period. The mixture is stirred at room temperature for 4 hours and the resulting precipitate is collected by vacuum filtration. The title compound is obtained in pure form after drying in vacuo.

Aufarbeitung

  1. filtrationthe resulting precipitate is collected by vacuum filtration

Quellen und Nachweise

ORD-Eintrag
ord-6bc8cc3a3cf447438669320059c53733
Quelldatensatz
uspto-grants-1994_12
Patentnummer
US05373010

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