Water → 2-Chloro-3-(trifluoromethyl)benzaldehyde

HRID 1494588Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1494588
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9].C([Li])CCC.CN(C)[CH:19]=[O:20].O>O1CCCC1.CCCCCC>[Cl:1][C:2]1[C:3]([C:8]([F:9])([F:10])[F:11])=[CH:4][CH:5]=[CH:6][C:7]=1[CH:19]=[O:20]

Komponenten

7

Edukt 4

HCID 962WaterHCID 6228DimethylformamideHCID 69211-Chloro-2-(trifluoromethyl)benzeneHCID 178418339Butyllithium

Produkt 1

HCID 27366722-Chloro-3-(trifluoromethyl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittel2×HCID 8058HexaneLösungsmittel

Versuchsvorschrift

A solution of 0.6 mole of 2-chlorotrifluoromethylbenzene in 1 l of tetrahydrofuran is cooled to -65° C. and 0.58 mole of butyllithium dissolved in hexane is added. The mixture is maintained at the same temperature for 2 hours and a mixture containing 44 ml of dimethylformamide and 200 ml of tetrahydrofuran is then added dropwise. The reaction medium is allowed to return to ambient temperature, 600 ml of water are added, extraction is then carried out with ethyl ether followed by evaporation to dryness. The product is distilled to purify.

Aufarbeitung

  1. additionis added
  2. temperatureThe mixture is maintained at the same temperature for 2 hours
  3. additionis then added dropwise
  4. customto return to ambient temperature
  5. extractionextraction
  6. customfollowed by evaporation to dryness
  7. distillationThe product is distilled
  8. customto purify

Quellen und Nachweise

ORD-Eintrag
ord-1614159ade804cd78bcf1e2671810759
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05026863

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