Water → 6-(4-Chlorobenzoyl)-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione

HRID 1500610Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1500610
Cl.[CH2:2]([N:5]1[C:10](=[O:11])[C:9]2[CH2:12][NH:13][CH2:14][CH2:15][C:8]=2[NH:7][C:6]1=[O:16])[C:3]#[CH:4].C(N(CC)CC)C.[Cl:24][C:25]1[CH:33]=[CH:32][C:28]([C:29](Cl)=[O:30])=[CH:27][CH:26]=1.O>C(Cl)Cl>[Cl:24][C:25]1[CH:33]=[CH:32][C:28]([C:29]([N:13]2[CH2:14][CH2:15][C:8]3[NH:7][C:6](=[O:16])[N:5]([CH2:2][C:3]#[CH:4])[C:10](=[O:11])[C:9]=3[CH2:12]2)=[O:30])=[CH:27][CH:26]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 85014-Chlorobenzoyl chlorideHCID 866631133-Propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione hydrochloride

Produkt 1

HCID 866631156-(4-Chlorobenzoyl)-3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3-propargyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione hydrochloride (790 mg) was suspended in methylene chloride, triethylamine (0.95 ml) and 4-chlorobenzoyl chloride (0.42 ml) were added under ice cooling and the resultant mixture was stirred at the same temperature for 30 minutes. To the reaction solution, water was added and the resultant mixture was concentrated. To the residue, diethyl ether was added and insoluble matter was separated by filtration to obtain the titled compound (894 mg) as a white powder. The resultant compound was used in a next reaction without further purifying.

Aufarbeitung

  1. concentrationthe resultant mixture was concentrated
  2. additionTo the residue, diethyl ether was added
  3. custominsoluble matter was separated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-8e705ba5bc344863b0bd715a0f1ae6f4
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09206173B2

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