Lithium hydroxide, monohydrate → lithium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

HRID 1500632

Reaktionsgleichung

Reaktionsgleichung von HRID 1500632
C[O:2][C:3]([C@H:5]1[CH2:9][O:8][C:7]([CH3:11])([CH3:10])[O:6]1)=[O:4].O.[OH-].[Li+:14]>CO.O>[CH3:10][C:7]1([CH3:11])[O:6][C@@H:5]([C:3]([O-:4])=[O:2])[CH2:9][O:8]1.[Li+:14]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 853166Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

Produkt 1

HCID 67153178lithium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylateAusbeute 96,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid methyl ester (5.0 g, 31.25 mmol) in MeOH (32.0 mL) at room temperature was added a solution of lithium hydroxide monohydrate (1.31 g, 31.25 mmol) in water (10.0 mL). The resulting mixture was stirred for thirty min before it was concentrated. The resulting white solid was further dried under vacuum to give the title compound (4.59 g).

Aufarbeitung

  1. concentrationwas concentrated
  2. customThe resulting white solid was further dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f650585eca2441ecb9ab575c02d1a92b
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09206172B2

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