Ammonium formate → 2-Phenylglycine

HRID 1502931

Reaktionsgleichung

Reaktionsgleichung von HRID 1502931
C(O[C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[CH:12]([O-:14])=[O:13].[NH4+:15]>[Ir].CO>[CH:8]1[CH:7]=[CH:6][C:5]([CH:4]([NH2:15])[C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1

Komponenten

5

Edukt 2

HCID 2723923Ammonium formateHCID 6422010Methanol, oxo-, benzoate

Produkt 1

HCID 38662-PhenylglycineAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23924IridiumKatalysatorHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

751 mg (5.0 mmol) of benzoyl formate (MW: 150.13), 946 mg (15.0 mmol) of ammonium formate (MW: 63.06), and 5.90 mg (0.01 mmol, S/C=500) of the iridium catalyst Ir-7 (MW: 590.13) were introduced in a 20-mL Schlenk tube and subjected to argon-gas replacement. 5 mL of dehydrated methanol was added and the mixture was stirred while heating at 60° C. for 1.5 hr. After distillation of the solvent, a crystal was collected by filtration, washed with methanol, dried under reduced pressure to give 718 mg of DL-2-phenylglycine (95% yield).

Aufarbeitung

  1. distillationAfter distillation of the solvent
  2. filtrationa crystal was collected by filtration
  3. washwashed with methanol
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e34fa047909245668f76cb4da8024c48
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09211533B2

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