2,3-Diaminobenzoic acid methyl ester → HCID 90229347, Verbindung

HRID 1505790

Reaktionsgleichung

Reaktionsgleichung von HRID 1505790
[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].Cl.N[C:15](OCC)=[CH:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]>CCO>[CH2:20]([O:19][C:17](=[O:18])[CH2:16][C:15]1[NH:12][C:11]2[CH:10]=[CH:9][CH:8]=[C:3]([C:4]([O:6][CH3:7])=[O:5])[C:2]=2[N:1]=1)[CH3:21]

Komponenten

4

Edukt 2

HCID 5718252,3-Diaminobenzoic acid methyl esterHCID 53395434Ethyl beta-amino-beta-ethoxyacrylate hydrochloride

Produkt 1

HCID 90229347HCID 90229347, VerbindungAusbeute 106,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of methyl 2,3-diaminobenzoate (680 mg) and ethyl 3-amino-3-ethoxyacrylate hydrochloride (880 mg) in EtOH (12 mL) was stirred at 60° C. for 2 hours. EtOH was removed under reduced pressure, and the residue was purified on column chromatography to obtain the titled compound (1.14 g) as a pale yellow solid.

Aufarbeitung

  1. customEtOH was removed under reduced pressure
  2. customthe residue was purified on column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-1b90bd2e121847489527c70af599b16e
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09216968B2

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