Dichloromethane → (3-Isopropoxyphenyl)methanol

HRID 1510151Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1510151
[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH:8]=[O:9])([CH3:3])[CH3:2].[BH4-].[Na+].C(Cl)Cl>CO>[CH:1]([O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[CH2:8][OH:9])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 6344Dichloromethane2×HCID 7129143-IsopropoxybenzaldehydeHCID 4311764Sodium borohydride

Produkt 1

HCID 2759474(3-Isopropoxyphenyl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a 1 molar solution of 3-isopropoxy benzaldehyde (102 g, 0.621 moles) in methanol (620 mL) cooled to 0° was added (slowly) sodium borohydride powder (25.8 g, 0.683 moles)-dissolved in a minimum of methylene chloride and passed through a plug of silica gel washing with more methylene chloride until the silica gel was free of the product. The eluent was stripped to an oil and pumped on high vacuum overnight.

Aufarbeitung

  1. custompumped on high vacuum overnight

Quellen und Nachweise

ORD-Eintrag
ord-bb2baadfd4414e958c89bb400d2de812
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08211904B2

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