Hydrochloric Acid → 2,6-Dibromo-3-pyridinecarboxylic acid

HRID 1512976Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1512976
[Br:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[C:4]([Br:10])[N:3]=1.P([O-])(O)(O)=[O:12].[Na+].CC(=CC)C.Cl([O-])=O.[Na+].Cl>C(O)(C)(C)C.O>[Br:1][C:2]1[N:3]=[C:4]([Br:10])[CH:5]=[CH:6][C:7]=1[C:8]([OH:12])=[O:9]

Komponenten

8

Edukt 5

HCID 313Hydrochloric AcidHCID 105532-Methyl-2-buteneHCID 122593842,6-Dibromopyridine-3-carbaldehydeHCID 23668197Sodium ChloriteHCID 23672064Monosodium phosphate

Produkt 1

HCID 122593872,6-Dibromo-3-pyridinecarboxylic acidAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittel3×HCID 6386tert-ButanolLösungsmittel

Versuchsvorschrift

To a solution of 2,6-dibromo-3-formylpyridine (0.3 g) in tert-butanol (12 mL)-water (1 mL) were added sodium dihydrogen phosphate (0.14 g), 2-methyl-2-butene (0.32 g) and a solution of sodium chlorite (0.36 g) in water (2 mL) successively at room temperature, and the mixture was stirred for 2 hours. The reaction mixture was poured into water. The mixture was acidified by adding 1 mol/L hydrochloric acid, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (0.28 g).

Aufarbeitung

  1. extractionthe resulting mixture was extracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bb873ee1f03747e2a1067c41fa17e7bf
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217069B2

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