(5-[(1,1-Dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate → {5-[(1,1-Dimethylethyl)thio]-4-oxo-1,4-dihydro-2-pyridinyl}methyl acetate
Reaktionsgleichung
[C:1]([O:4][CH2:5][C:6]1[CH:11]=[C:10]([O:12]CC2C=CC=CC=2)[C:9]([S:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:8][N:7]=1)(=[O:3])[CH3:2]>O1CCOCC1.O.[Pd]>[C:1]([O:4][CH2:5][C:6]1[NH:7][CH:8]=[C:9]([S:20][C:21]([CH3:24])([CH3:23])[CH3:22])[C:10](=[O:12])[CH:11]=1)(=[O:3])[CH3:2]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of (5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (6 g) in 1,4-dioxane/water (100 ml/50 ml) was hydrogenated at atmospheric pressure with 10% palladium on charcol (7 g) overnight. Filtration and evaporation afforded a white solid (4.46 g, 95%).