Hydrochloric Acid → 4-(3-Butyl-4-cyano-2-methylpyrrole-1-yl)benzoic acid
Reaktionsgleichung
C([O:3][C:4](=[O:23])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH:15]=[C:14]([C:16]#[N:17])[C:13]([CH2:18][CH2:19][CH2:20][CH3:21])=[C:12]2[CH3:22])=[CH:7][CH:6]=1)C.O.[OH-].[Li+].Cl>C(O)C.O>[CH2:18]([C:13]1[C:14]([C:16]#[N:17])=[CH:15][N:11]([C:8]2[CH:7]=[CH:6][C:5]([C:4]([OH:23])=[O:3])=[CH:10][CH:9]=2)[C:12]=1[CH3:22])[CH2:19][CH2:20][CH3:21]Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
A suspension of 4-(3-butyl-4-cyano-2-methylpyrrole-1-yl)benzoic acid ethyl ester (0.030 g) and lithium hydroxide mono hydrate (0.041 g) in ethanol (2 mL) and water (1 mL) was stirred at 50° C. for 2 hours. To this reaction mixture was added 1 mol/L hydrochloric acid (5 mL), and this mixture was stirred at room temperature for 30 minutes. This reaction mixture was extracted with ethyl acetate, and this organic layer was washed with water, dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (0.027 g).
Aufarbeitung
- stirringthis mixture was stirred at room temperature for 30 minutes
- extractionThis reaction mixture was extracted with ethyl acetate
- washthis organic layer was washed with water
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was removed under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-483026c7d8694330be97237363e9c6c9
- Quelldatensatz
- uspto-grants-2012_07
- Patentnummer
- US08227500B2
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