Acetonitrile → HCID 178510289, Verbindung

HRID 1516601Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1516601
[C:1]([C:3]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][N:5]([C:14]2[CH:15]=[C:16]([CH:20]=[CH:21][N:22]=2)[C:17]([NH2:19])=O)[CH:4]=1)#[N:2].[N-:23]=[N+:24]=[N-:25].[Na+].C(#N)C.Cl[Si](Cl)(Cl)Cl>O.O1CCCC1>[C:8]1([C:7]2[C:3]([C:1]#[N:2])=[CH:4][N:5]([C:14]3[CH:15]=[C:16]([C:17]4[NH:25][N:24]=[N:23][N:19]=4)[CH:20]=[CH:21][N:22]=3)[CH:6]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

7

Edukt 4

HCID 6342AcetonitrileHCID 24816Silicon tetrachlorideHCID 33557Sodium AzideHCID 685087634-Pyridinecarboxamide, 2-(3-cyano-4-phenyl-1H-pyrrol-1-yl)-

Produkt 1

HCID 178510289HCID 178510289, VerbindungAusbeute 80,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of 2-(3-cyano-4-phenylpyrrole-1-yl)isonicotinamide (0.058 g) and sodium azide (0.039 g) in a mixed solvent of acetonitrile (1.0 mL) and tetrahydrofuran (0.5 mL) was added tetrachlorosilane (0.068 g) at room temperature, and this mixture was stirred at 80° C. overnight. To this reaction mixture was added water, this obtained solid was collected by filtration. After washing with water, this solid was dried at 50° C. under reduced pressure to give the title compound (0.051 g).

Aufarbeitung

  1. filtrationthis obtained solid was collected by filtration
  2. washAfter washing with water
  3. customthis solid was dried at 50° C. under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-969bb23284bf43998d61325c7269c29b
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08227500B2

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