Water → 1-[4-(Isobutylamino)-3-nitrophenyl]ethanone

HRID 1517181

Reaktionsgleichung

Reaktionsgleichung von HRID 1517181
F[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].C(=O)([O-])O.[Na+].[CH2:19]([NH2:23])[CH:20]([CH3:22])[CH3:21].O>C(#N)C>[CH2:19]([NH:23][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12])[CH:20]([CH3:22])[CH3:21]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6558IsobutylamineHCID 516892Sodium BicarbonateHCID 27346124'-Fluoro-3'-nitroacetophenone

Produkt 1

HCID 595690481-[4-(Isobutylamino)-3-nitrophenyl]ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To 24.5 g (133.8 mM) of 1-(4-fluoro-3-nitrophenyl)ethanone in 100 ml of acetonitrile and 11.2 g (133.8 mM) of sodium hydrogen carbonate are added 26.6 ml (267.6 mM) of isobutylamine. The reaction is exothermic: the temperature of the reaction medium is maintained below 50° C. and the resulting mixture is then stirred for 1 hour at room temperature. Demineralised water is added, and a solid precipitates out. The solid is filtered off and washed with water to give after drying 31.6 g of 1-[4-(isobutylamino)-3-nitrophenyl]ethanone in quantitative yield.

Aufarbeitung

  1. temperaturethe temperature of the reaction medium is maintained below 50° C.
  2. customa solid precipitates out
  3. filtrationThe solid is filtered off
  4. washwashed with water
  5. customto give
  6. dry with materialafter drying 31.6 g of 1-[4-(isobutylamino)-3-nitrophenyl]ethanone in quantitative yield

Quellen und Nachweise

ORD-Eintrag
ord-d1b9e679c18e4b1e8d15eb12e8d91bac
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232272B2

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