Water → Didecyldimethylammonium 2-[(2,6-dichlorophenyl)amino]benzeneacetate

HRID 1517222Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1517222
[Cl-].[CH2:2]([N+:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])([CH3:14])[CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].O.[CH:26]1[CH:31]=[C:30]([CH2:32][C:33]([O-:35])=[O:34])[C:29]([NH:36][C:37]2[C:42]([Cl:43])=[CH:41][CH:40]=[CH:39][C:38]=2[Cl:44])=[CH:28][CH:27]=1.[Na+]>C(Cl)(Cl)Cl>[Cl:43][C:42]1[CH:41]=[CH:40][CH:39]=[C:38]([Cl:44])[C:37]=1[NH:36][C:29]1[CH:28]=[CH:27][CH:26]=[CH:31][C:30]=1[CH2:32][C:33]([O-:35])=[O:34].[CH2:15]([N+:12]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])([CH3:14])[CH3:13])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]

Komponenten

5

Edukt 3

HCID 962WaterHCID 23558Didecyldimethylammonium ChlorideHCID 5018304Diclofenac sodium

Produkt 1

HCID 69294875Didecyldimethylammonium 2-[(2,6-dichlorophenyl)amino]benzeneacetateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Didecyldimethylammonium chloride (0.03 mol) was dissolved in 40 mL distilled water and diclofenac sodium salt (0.04 mol) was added to the solution. The solution was stirred at room temperature for 30 min. Chloroform (40 mL) was added to the reaction mixture and the mixture was stirred. After separation of the phases, the organic phase was washed with 40 mL distilled, cold water until chloride ions were no longer detected using AgNO3. Chloroform was removed and the residue was dried at 50° C. in vacuum. The product, didecyldimethylammonium 2-[(2,6-dichlorophenyl)amino]benzeneacetate (100% yield), was obtained as a grease that is soluble in chloroform, acetone, and DMSO. The product lacks miscibility with water and hexane. Thermogravimetric analysis: Tonset5%=162° C., and Tonset=183° C. 1H and 13C NMR (DMSO) were obtained.

Aufarbeitung

  1. additionwas added to the solution
  2. stirringthe mixture was stirred
  3. customAfter separation of the phases
  4. washthe organic phase was washed with 40 mL
  5. distillationdistilled
  6. customChloroform was removed
  7. customthe residue was dried at 50° C. in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-037329b8b688443faae99a68f7cf508b
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232265B2

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