1-Phenylpiperazine → 4-(4-Methyl-1-piperazinyl)phenol

HRID 1518368

Reaktionsgleichung

Reaktionsgleichung von HRID 1518368
S1C2C=CC=CC=2N=C1N(COCC[Si](C)(C)C)C(C1C=CC=C2C=1CN(C1SC([CH2:32][N:33]3[CH2:38][CH2:37][N:36]([C:39]4[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=4)[CH2:35][CH2:34]3)=C(C(OC)=O)N=1)CC2)=O.S1C2C=CC=CC=2N=C1NC(C1C=CC=C2C=1CN(C1SC(CCCCI)=C(C(OCC)=O)N=1)CC2)=[O:64].C1C=CC(N2CCNCC2)=CC=1.N1(C2C=CC(O)=CC=2)CCNCC1>>[CH3:32][N:33]1[CH2:38][CH2:37][N:36]([C:39]2[CH:44]=[CH:43][C:42]([OH:64])=[CH:41][CH:40]=2)[CH2:35][CH2:34]1

Komponenten

5

Edukt 4

HCID 70961-PhenylpiperazineHCID 92467p-(1-Piperazinyl)phenolHCID 59447633ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-iodobutyl)thiazole-4-carboxylateHCID 59447670methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-((4-phenylpiperazin-1-yl)methyl)thiazole-4-carboxylate

Produkt 1

HCID 116224864-(4-Methyl-1-piperazinyl)phenol

Versuchsvorschrift

Compound 82A was prepared in a similar manner to the synthesis of compound 62A by substituting compound 42C and phenylpiperazine with paraformahyde and 4-(piperazin-1-yl)phenol, respectively: 1H NMR (DMSO-d6): δ 6.74-6.78 (m, 2H), 6.61-6.65 (m, 2H), 2.93-2.95 (m, 4H), 2.41-2.44 (m, 4H), 2.22 (s, 3H). ESI (+)/MS: 193 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-c44754f63d45453c8eabc1be3f99d5d3
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08232273B2

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