Lithium hydroxide, monohydrate → HCID 86673816, Verbindung

HRID 1527268Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1527268
C[O:2][C:3](=[O:17])[CH2:4][C:5]1[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]2=[C:7]([C:14](=[O:16])[CH3:15])[N:6]=1.O[Li:19].O>C1COCC1.O>[C:14]([C:7]1[N:6]=[C:5]([CH2:4][C:3]([O-:17])=[O:2])[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=12)(=[O:16])[CH3:15].[Li+:19]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 68283887HCID 68283887, Verbindung

Produkt 1

HCID 86673816HCID 86673816, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of (1-acetyl-imidazo[1,5-a]pyridin-3-yl)-acetic acid methyl ester (1.12 g, 4.82 mmol) in THF (15 mL) and water (7.5 mL) was added LiOH.H2O (202 mg, 4.82 mmol). The reaction was stirred at RT for 5.5 h until completion of the reaction. The mixture was concentrated under reduced pressure and the material thus obtained was used in the next step without further purification: MS (UPLC/MS): 219.2 [M+H]+, 241.2 [M+Na]+, 217.2 [M−H]−; tR (HPLC conditions f): 1.03 min.

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe material thus obtained
  3. customwas used in the next step without further purification
  4. custom1.03 min.

Quellen und Nachweise

ORD-Eintrag
ord-4f719a47138746469d7ba26284c64fed
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09085555B2

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