Lithium Hydroxide → 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxylic acid

HRID 1530668Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1530668
[CH:1]([N:4]1[C:8]([C:9]2[N:10]=[C:11]3[C:17]4[CH:18]=[CH:19][C:20]([C:22]([O:24]C)=[O:23])=[CH:21][C:16]=4[O:15][CH2:14][CH2:13][N:12]3[CH:26]=2)=[N:7][C:6]([CH3:27])=[N:5]1)([CH3:3])[CH3:2].[OH-].[Li+]>O1CCCC1.O>[CH:1]([N:4]1[C:8]([C:9]2[N:10]=[C:11]3[C:17]4[CH:18]=[CH:19][C:20]([C:22]([OH:24])=[O:23])=[CH:21][C:16]=4[O:15][CH2:14][CH2:13][N:12]3[CH:26]=2)=[N:7][C:6]([CH3:27])=[N:5]1)([CH3:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 3939Lithium HydroxideHCID 68313138Methyl 2-(2-isopropyl-5-methyl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-9-carboxylate

Produkt 1

HCID 683132352-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of methyl 2-(2-isopropyl-5-methyl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-9-carboxylate; (4.50 g, 12.2 mmol) in Tetrahydrofurane; (100 mL) was added a slurry of Lithium Hydroxide (880 mg, 36.7 mmol) in water (20 mL). The reaction mixture was stirred at room temperature for 1 hour. LC-MS analysis of the reaction mixture showed no more starting material. The solvent was removed and the residue was used in the next step without further purification.

Aufarbeitung

  1. customThe solvent was removed
  2. customthe residue was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-87d87f35621045beb263a5ed24e4a4ac
Quelldatensatz
uspto-grants-2015_07
Patentnummer
US09090628B2

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