(4-tert-Butoxycarbonylamino-2-nitro-phenylamino)-acetic acid tert-butyl ester → HCID 67199974, Verbindung

HRID 15532

Reaktionsgleichung

Reaktionsgleichung von HRID 15532
[C:1]([O:5][C:6](=[O:26])[CH2:7][NH:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])=[CH:11][C:10]=1[N+:23]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:26])[CH2:7][NH:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])=[CH:11][C:10]=1[NH2:23])([CH3:2])([CH3:4])[CH3:3]

Komponenten

4

Edukt 1

HCID 67201113(4-tert-Butoxycarbonylamino-2-nitro-phenylamino)-acetic acid tert-butyl ester

Produkt 1

HCID 67199974HCID 67199974, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

The product of step b.) (2.0 g, 5.45 mmol) was stirred with 3% Pd/C (200 mg) in ethanol (20 mL) under H2 (1 atm) for 90 minutes. The reaction was filtered over celite and concentrated to dryness to give the sub-title compound as a brown oil. This compound was used in crude form without purification. MS: ESI (positive): 338 (M+H).

Aufarbeitung

  1. filtrationThe reaction was filtered over celite and
  2. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-87a849f7a0c44fe2bcd1487199a27e08
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732618B2

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