Reaktionsgleichung
[C:1](Cl)(=[O:3])[CH3:2].[C:5]([O:9][C:10](=[O:32])[CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][C:19]([NH:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:20][C:15]=2[N:14]=[C:13]1[CH2:29][CH2:30][CH3:31])([CH3:8])([CH3:7])[CH3:6].CCN(C(C)C)C(C)C>CN(C1C=CN=CC=1)C.C(Cl)Cl.Cl>[C:5]([O:9][C:10](=[O:32])[CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][C:19]([N:21]([C:1](=[O:3])[CH3:2])[CH2:22][C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)=[CH:20][C:15]=2[N:14]=[C:13]1[CH2:29][CH2:30][CH3:31])([CH3:8])([CH3:7])[CH3:6]Komponenten
7
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
Acetyl chloride (25 μL, 0.36 mmol) was added to a solution of (5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester (45 mg, 0.12 mmol), DIEA (41 μL, 0.24 mmol) and DMAP (15 mg, 0.12 mmol) in CH2Cl2 (1 mL), and stirred overnight at room temperature. The reaction solution was diluted with aqueous HCl (1.0 M) and filtered through an Extrelut column. The Extrelut column was washed with CH2Cl2, and the filtrate was concentrated to afford the subtitle compound that was used without further purification. MS calculated for C25H31N3O3+H: 422, observed: 422.
Aufarbeitung
- filtrationfiltered through an Extrelut column
- washThe Extrelut column was washed with CH2Cl2
- concentrationthe filtrate was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-7fe19e508c9a44cc89f2b7f9100f8e99
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07732618B2
Verknüpfte Notizen
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