Sodium Thiosulfate → 4-Bromo-2-fluoro-3,5-dimethylphenol

HRID 15642

Reaktionsgleichung

Reaktionsgleichung von HRID 15642
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[CH:4][C:3]=1[CH3:10].[O-]S(C(F)(F)[F:16])(=O)=O.F[N+]1C=CC=CC=1.S([O-])([O-])(=O)=S.[Na+].[Na+]>ClCCCl>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([OH:9])=[C:4]([F:16])[C:3]=1[CH3:10]

Komponenten

5

Edukt 3

HCID 24477Sodium ThiosulfateHCID 819704-Bromo-3,5-dimethylphenolHCID 2724576Pyridinium, 1-fluoro-, 1,1,1-trifluoromethanesulfonate (1:1)

Produkt 1

HCID 593425984-Bromo-2-fluoro-3,5-dimethylphenolAusbeute 36,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-bromo-3,5-dimethylphenol (2.00 g, 9.95 mmol) in 1,2-dichloroethane (20 mL) was added N-fluoropyridinium triflate (6.15 g, 24.9 mmol), and the mixture was heated under reflux for 7 hr. The reaction mixture was treated with 1 M aqueous sodium thiosulfate solution, and extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=0:100-30:70) to give the title compound (0.790 g, yield 36%) as a colorless oil.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 7 hr
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed successively with water and saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=0:100-30:70)

Quellen und Nachweise

ORD-Eintrag
ord-cbdc6c6d5028454a97a4fb8644a9ff86
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732626B2

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