[C:1](OC(=O)C)(=[O:3])[CH3:2].[Cl:8][C@H:9]1[CH2:29][C@@:28]2([CH3:30])[C@@H:20]([CH2:21][C@H:22]([CH3:37])[C@:23]2([O:31][C:32](=[O:36])[CH:33]([CH3:35])[CH3:34])[C:24](=[O:27])[CH2:25][OH:26])[C@H:19]2[C@H:10]1[C@:11]1([CH3:39])[C:16]([CH2:17][CH2:18]2)=[CH:15][C:14](=[O:38])[CH:13]=[CH:12]1.O.Cl>N1C=CC=CC=1>[C:1]([O:26][CH2:25][C:24](=[O:27])[C@:23]1([O:31][C:32](=[O:36])[CH:33]([CH3:35])[CH3:34])[C@:28]2([CH3:30])[C@H:20]([C@H:19]3[C@H:10]([C@@H:9]([Cl:8])[CH2:29]2)[C@:11]2([CH3:39])[C:16](=[CH:15][C:14](=[O:38])[CH:13]=[CH:12]2)[CH2:17][CH2:18]3)[CH2:21][C@@H:22]1[CH3:37])(=[O:3])[CH3:2]Acetic anhydride (0.22 ml.) was added to a solution of 11β-chloro-21-hydroxy-17-isobutyryloxy-16β-methylpregna-1,4-diene-3,20 dione (71 mg.) in pyridine (1 ml.) at room temperature. After 3.5 hours, a little water was added and the solution was poured into dilute hydrochloric acid. Filtration of the precipitated solid and crystallization from methanol afforded the title compound, m.p. 204°-205° (K), [α]D + 95.2 (c 0.6 chloroform) λmax 240 nm (ε 15,450) (Found: C, 67.05; H, 7.4; Cl, 7.05, C28H37Cl O6 requires C, 66.6; H, 7.4; Cl, 7.0%).
Wird geladen…