Propionic anhydride → 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline

HRID 1581127

Reaktionsgleichung

Reaktionsgleichung von HRID 1581127
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH2:12])[C:6]([NH2:13])=[N:5]2.[C:14](OC(=O)CC)(=O)[CH2:15][CH3:16]>C(O)(=O)CC>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]1[NH:12][C:14]([CH2:15][CH3:16])=[N:13][C:6]1=[N:5]2

Komponenten

4

Edukt 2

HCID 31263Propionic anhydrideHCID 125173906-Chloroquinoxaline-2,3-diamine

Produkt 1

HCID 1784375416-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxalineAusbeute 88,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1032Propionic AcidLösungsmittel

Versuchsvorschrift

78 G (0.4 mole) of 6-chloro-2,3-diamino-quinoxaline were dissolved in 500 ml of anhydrous propionic acid and 105 g (0.8 mole) of propionic anhydride were added thereto. The reaction mixture was heated to the boil under reflux for 5 hours. After cooling, the solvent was distilled off in vacuo, the residue was taken up in dilute sodium hydroxide solution, the mixture was filtered, the filtrate was acidified with dilute hydrochloric acid and the resulting precipitate was filtered off. It was well washed with water and dried in vacuo at 110°C. 82 g (representing 88% of theory) of 6-chloro-2-ethyl-1H-imidazo[4,5-b]quinoxaline of melting point 190°C (decomposition) were obtained.

Aufarbeitung

  1. temperatureThe reaction mixture was heated to the boil
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling
  4. distillationthe solvent was distilled off in vacuo
  5. filtrationthe mixture was filtered
  6. filtrationthe resulting precipitate was filtered off
  7. washIt was well washed with water
  8. customdried in vacuo at 110°C

Quellen und Nachweise

ORD-Eintrag
ord-4bd62135f66047e2a7e1e1aa37a7afa4
Quelldatensatz
uspto-grants-1976_01
Patentnummer
US03935312

Verknüpfte Notizen

Wird geladen…