Water → (4-(2-Fluoroethoxy)phenyl)methanol

HRID 1583582

Reaktionsgleichung

Reaktionsgleichung von HRID 1583582
[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1.[BH4-].[Na+].O>C(O)C>[F:1][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][OH:10])=[CH:7][CH:6]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 4311764Sodium borohydride2×HCID 150586494-(2-Fluoroethoxy)benzaldehyde

Produkt 1

HCID 13367643(4-(2-Fluoroethoxy)phenyl)methanolAusbeute 89,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The crude 4-(2-fluoroethoxy)benzaldehyde (35.6 g) was dissolved in 140 ml of ethanol, and 11.0 g of sodium borohydride was carefully added to the solution at 47° to 50° C. After adding sodium borohydride, the reaction was carried out at 50° C. for 2 hours. After the reaction, the reaction mixture was cooled to room temperature and water was added. The mixture was extracted with toluene. The toluene layer was washed with water and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure to give 32.4 g of 4-(2-fluoroethoxy)benzyl alcohol as crystals (m.p. 37.3°-38.0° C.).

Aufarbeitung

  1. customAfter the reaction
  2. extractionThe mixture was extracted with toluene
  3. washThe toluene layer was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customToluene was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-346c693605af4bd19f5fe687b931aa98
Quelldatensatz
uspto-grants-1985_11
Patentnummer
US04552894

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