Glycine → HCID 19597249, Verbindung

HRID 1586550Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1586550
[OH-].[Na+].Cl[C:4]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].[NH2:14][CH2:15][C:16]([OH:18])=[O:17].C(=O)([O-])[O-].[K+].[K+]>O.C(=O)([O-])[O-].[Cu+2]>[C:16]([CH:15]=[N:14][C:4]1[C:5](=[CH:9][CH:10]=[C:11]([Cl:13])[CH:12]=1)[C:6]([OH:8])=[O:7])([OH:18])=[O:17]

Komponenten

7

Edukt 4

HCID 750GlycineHCID 57872,4-Dichlorobenzoic AcidHCID 11430Potassium CarbonateHCID 14798Sodium Hydroxide

Produkt 1

HCID 19597249HCID 19597249, VerbindungAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14452Copper carbonateKatalysatorHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

20 g (0.5 mol) of NaOH are dissolved in 100 ml of water, and 38.2 g (0.2 mol) of 2,4-dichlorobenzoic acid, 22.5 g (0.3 mol) of glycine and 1.4 g (6 mmol) of basic copper carbonate are added. The mixture is heated to 80° C., and 28 g (0.2 mol) of potassium carbonate are added. It is heated at 100° C. for 3 h. The filtrate after filtration with suction while hot is added to 100 ml of water and adjusted to pH 1-2 with hydrochloric acid. The product then precipitates and is filtered with suction and dried. 41 g (0.18 mol; 89%) of N-carboxymethylene-4-chloroanthranilic acid are obtained.

Aufarbeitung

  1. temperatureIt is heated at 100° C. for 3 h
  2. filtrationThe filtrate after filtration with suction
  3. additionwhile hot is added to 100 ml of water
  4. customThe product then precipitates
  5. filtrationis filtered with suction
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5b048905c5294dde8c467d7b1b7a02a3
Quelldatensatz
uspto-grants-1999_08
Patentnummer
US05945556

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