Cannabinol → Tetrahydrocannabinol

HRID 1587661Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1587661
O1CCCC1.[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]([OH:28])[C:14]2[C:15]3[CH:16]=[C:17]([CH3:27])[CH:18]=[CH:19][C:20]=3[C:21]([CH3:26])([CH3:25])[O:22][C:23]=2[CH:24]=1.[BH4-].[Na+]>O>[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[C:13]([OH:28])[C:14]2[C@@H:15]3[CH:16]=[C:17]([CH3:27])[CH2:18][CH2:19][C@H:20]3[C:21]([CH3:26])([CH3:25])[O:22][C:23]=2[CH:24]=1

Komponenten

5

Edukt 3

HCID 2543CannabinolHCID 8028TetrahydrofuranHCID 4311764Sodium borohydride

Produkt 1

HCID 16078Tetrahydrocannabinol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Five ml of tetrahydrofuran containing 38.75 mg of a cannabinol derivative having the formula ##STR4## were added to the activated-LPS effluent, and the mixture was incubated for 18 hours at 22° C. in the dark. Two ml of a solution of 4.5 mg/ml NaBH4 in H2O were added, and the mixture was incubated for 30 minutes at room temperature. Unconjugated THC derivative was removed by dialysis for 2 days against frequent changes of water and for 2 days against 0.1M acetic acid, pH 3.5, to yield a THC-LPS conjugate.

Aufarbeitung

  1. additionwere added to the activated-LPS effluent, and the mixture
  2. waitthe mixture was incubated for 30 minutes at room temperature
  3. customUnconjugated THC derivative was removed by dialysis for 2 days against frequent changes of water and for 2 days against 0.1M acetic acid, pH 3.5

Quellen und Nachweise

ORD-Eintrag
ord-f9d9a26bcc7743459fc9ad768ac6d626
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05219747

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