Sodium Acetate → N-(3-Cyano-4-ethoxythiophen-2-yl)acetamide

HRID 1591285Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1591285
[C:1]([O-])(=[O:3])[CH3:2].[Na+].CC(OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=O.[NH2:30][C:31]1[S:32][CH:33]=[C:34]([O:38][CH2:39][CH3:40])[C:35]=1[C:36]#[N:37]>O>[C:1]([NH:30][C:31]1[S:32][CH:33]=[C:34]([O:38][CH2:39][CH3:40])[C:35]=1[C:36]#[N:37])(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 517045Sodium AcetateHCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterHCID 137423802-Amino-4-ethoxythiophene-3-carbonitrile

Produkt 1

HCID 13742383N-(3-Cyano-4-ethoxythiophen-2-yl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

100 parts of anhydrous sodium acetate are introduced into 400 parts by volume of acetic anhydrice, 168 parts of 2-amino-3-cyano-4-ethoxythiophene are added and the mixture is refluxed for 4 hours. Thereafter, 800 parts of water are added dropwise to the hot mixture, the mixture is left to cool and the product is filtered off under suction, washed with water and dried to give 194 parts of 2-acetylamino-3-cyano-4-ethoxythiophene of melting point 242°-243° C. (from acetic acid).

Aufarbeitung

  1. additionare added
  2. temperaturethe mixture is refluxed for 4 hours
  3. waitthe mixture is left
  4. temperatureto cool
  5. filtrationthe product is filtered off under suction
  6. washwashed with water
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4896cfd6cedd464f922884e9b88f535a
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05206375

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