Thiophenol → 2-Amino-3-cyano-5-formyl-4-phenylthiothiophene

HRID 1591298Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1591298
[NH2:1][C:2]1[S:3][C:4]([CH:10]=[O:11])=[C:5](Cl)[C:6]=1[C:7]#[N:8].[C:12]1([SH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C[O-].[Na+]>CO>[NH2:1][C:2]1[S:3][C:4]([CH:10]=[O:11])=[C:5]([S:18][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]=1[C:7]#[N:8]

Komponenten

5

Edukt 3

HCID 7969ThiophenolHCID 27376122-Amino-4-chloro-5-formyl-3-thiophenecarbonitrileHCID 10942334Sodium Methoxide

Produkt 1

HCID 197667672-Amino-3-cyano-5-formyl-4-phenylthiothiopheneAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

18.7 parts of 2-amino-4-chloro-3-cyano-5-formylthiophene are added to a solution of 11 parts of thiophenol, 5.4 parts of a 30% strength methanolic sodium methylate solution and 100 parts of methanol. The mixture is heated at the boil for 0.5 hour, after which it is allowed to cool and the precipitated product is filtered off under suction, washed with methanol, and then with water and dried. 21 parts (81% of theory) of 2-amino-3-cyano-5-formyl-4-phenylthiothiophene are obtained.

Aufarbeitung

  1. temperatureThe mixture is heated at the boil for 0.5 hour
  2. temperatureto cool
  3. filtrationthe precipitated product is filtered off under suction
  4. washwashed with methanol
  5. dry with materialwith water and dried

Quellen und Nachweise

ORD-Eintrag
ord-70ddab2daf19419bbaa22ed55c413ed2
Quelldatensatz
uspto-grants-1993_04
Patentnummer
US05206375

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