Ammonium formate → HCID 10934154, Verbindung

HRID 1593477Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1593477
C1([C@@H]([NH:9][C@H:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][C@@H:11]2[C:23]([O:25][CH3:26])=[O:24])C)C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[NH2:9][C@H:10]1[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:17])[CH2:12][C@@H:11]1[C:23]([O:25][CH3:26])=[O:24]

Komponenten

5

Edukt 2

HCID 2723923Ammonium formateHCID 58745501HCID 58745501, Verbindung

Produkt 1

HCID 10934154HCID 10934154, VerbindungAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 260A (1.10 g, 3.03 mmol) in MeOH (31 mL) at room temperature was treated with ammonium formate (1.51 g, 24.3 mmol) and 10% Pd/C (110 mg). The reaction mixture was heated to reflux for 14 hours then cooled to room temperature. The solid material was removed by filtration and washed with MeOH. The filtrate was concentrated in vacuo to give 0.75 g (yield: 96%) of Compound 260B as an oil.

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 14 hours
  3. customThe solid material was removed by filtration
  4. washwashed with MeOH
  5. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-89d2a62411554ddba61dab644476d38b
Quelldatensatz
uspto-grants-2007_11
Patentnummer
US07297695B2

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