Sodium Thiosulfate → (R)-2-Methyl-4,4,4-trifluorobutanal

Temperatur

25 °C

To (2R)-4,4,4-trifluoro-2-methylbutan-1-ol (2.90 g, 20.4 mmol) in CH2Cl2 (50 mL) at 0° C. was added Dess-Martin periodinane (10.24 g, 24.49 mmol). After 15 min, the reaction mixture was warmed to 25° C. and stirred for 1 h. This mixture was then diluted with diethyl ether (50 mL) and added to Na2S2O3 (11.29 g, 71.44 mmol) dissolved in a saturated solution of aqueous NaHCO3 (100 mL). The milky white mixture was stirred until both layers were homogeneous. The phases were separated and the organic extract was dried (MgSO4) and filtered to give a solution of (2R)-4,4,4-trifluoro-2-methylbutanal which was used in the next step without removal of solvents.

1. stirringThe milky white mixture was stirred until both layers
2. customThe phases were separated
3. extractionthe organic extract
4. dry with materialwas dried (MgSO4)
5. filtrationfiltered

ORD-Eintrag

ord-157d631fcbd340cba8fe07c51fa7bca7

Quelldatensatz

uspto-grants-2007_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07300951B2