Water → HCID 21698925, Verbindung

HRID 1597185Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1597185
[F:1][C:2]1[C:12]([N:13]2[C:21](=[O:22])[C:20]3[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=3[C:14]2=[O:23])=[C:11]([N+:24]([O-])=O)[C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=1.O>C(O)(=O)C.[Fe]>[NH2:24][C:11]1[C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=[C:2]([F:1])[C:12]=1[N:13]1[C:21](=[O:22])[C:20]2[CH2:19][CH2:18][CH2:17][CH2:16][C:15]=2[C:14]1=[O:23]

Komponenten

5

Edukt 2

HCID 962WaterHCID 21698918HCID 21698918, Verbindung

Produkt 1

HCID 21698925HCID 21698925, VerbindungAusbeute 104,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2-[7-Fluoro-5-nitro-2H-1,4-benzoxazine-3(4H)-on-6-yl]-4,5,6,7-tetrahydro-2H-isoindole-1,3-dione (1.25 g) was dissolved in acetic acid (13 ml) and iron powder (0.77 g) was added with stirring. Solution was stirred at ambient temperature for 12 hr and water was added. Product was extracted with ethyl acetate to afford the title compound (1.2 g).

Aufarbeitung

  1. stirringSolution was stirred at ambient temperature for 12 hr
  2. extractionProduct was extracted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-8fa45bbf7e774577af0afe6034ac7418
Quelldatensatz
uspto-grants-2001_09
Patentnummer
US06294503B1

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