2-Amino-1-phenylpropan-1-ol hydrochloride → (1S,2R)-(+)-Norephedrine

HRID 1598295

Reaktionsgleichung

Reaktionsgleichung von HRID 1598295
[CH3:1][CH:2]([NH2:11])[CH:3]([OH:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.Cl.[OH-].[Na+]>O>[CH3:1][CH:2]([NH2:11])[CH:3]([OH:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 90652-Amino-1-phenylpropan-1-ol hydrochlorideHCID 14798Sodium Hydroxide

Produkt 1

HCID 4786(1S,2R)-(+)-Norephedrine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

Phenylpropanolamine hydrochloride was dissolved in the water and to this solution there was added, rapidly with stirring, 20 gm of sodium hydroxide dissolved in 100 ml of water. The mixture was allowed to stand at 10° C. overnight. Crystals of the free base were filtered, washed with water and dried in vacuum over calcium chloride. This process yielded 59 gm of free base phenylpropanolamine.

Aufarbeitung

  1. additionwas added
  2. filtrationCrystals of the free base were filtered
  3. washwashed with water
  4. dry with materialdried in vacuum over calcium chloride

Quellen und Nachweise

ORD-Eintrag
ord-8f8fd49571a64745887468f718f48809
Quelldatensatz
uspto-grants-1998_04
Patentnummer
US05736573

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