Sodium Dithionite → 1,3-Di-cyclopropyl-8-amino Xanthine

HRID 1602138

Reaktionsgleichung

Reaktionsgleichung von HRID 1602138
[CH:1]1([N:4]2[C:13](=[O:14])[C:12]3[NH:11][C:10]([N+:15]([O-])=O)=[N:9][C:8]=3[N:7]([CH:18]3[CH2:20][CH2:19]3)[C:5]2=[O:6])[CH2:3][CH2:2]1.S(S([O-])=O)([O-])=O.[Na+].[Na+]>CO.O>[CH:1]1([N:4]2[C:13](=[O:14])[C:12]3[NH:11][C:10]([NH2:15])=[N:9][C:8]=3[N:7]([CH:18]3[CH2:20][CH2:19]3)[C:5]2=[O:6])[CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 24489Sodium DithioniteHCID 98384921,3-Di-cyclopropyl-8-nitro xanthine

Produkt 1

HCID 98136211,3-Di-cyclopropyl-8-amino Xanthine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

1,3-Di-cyclopropyl-8-nitro xanthine (0.4 g, 0.0014 mol) was dissolved in methanol (20 ml) and treated with a sodium dithionite solution in water (0.5 g in 5 ml) at room temperature with stirring. After stirring for three hours the solvent was removed in vacuo, the residue taken up with dichloromethane and extracted with water (40 ml).

Aufarbeitung

  1. stirringAfter stirring for three hours the solvent
  2. customwas removed in vacuo
  3. extractionextracted with water (40 ml)

Quellen und Nachweise

ORD-Eintrag
ord-109637f7e434403aa6fe7ef695e85977
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05981535

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